ABSTRACT
COVID-19 raises attention to epidemic transmission in various places. This study analyzes the transmission risks associated with human activity places at multiple scales, including different types of settlements and eleven types of specific establishments (restaurants, bars, etc.), using COVID-19 data in 906 urban areas across four continents. Through a difference-in-difference approach, we identify the causal effects of activities at various places on epidemic transmission. We find that at the micro-scale, though the transmission risks at different establishments differ across countries, sports, entertainment, and catering establishments are generally more infectious. At the macro-scale, contradicting common beliefs, it is consistent across countries that transmission does not increase with settlement size and density. It is also consistent that specific establishments play a lesser role in transmission in larger settlements, suggesting more transmission happening elsewhere. These findings contribute to building a system of knowledge on the linkage between places, human activities, and disease transmission.
ABSTRACT
The COVID-19 pandemic has resulted in cities implementing lockdown measures, causing unprecedented disruption (e.g. school/shop/office closures) to urban life often extending over months. With the spread of COVID-19 now being relatively contained, many cities have started to ease their lockdown restrictions by phases. Following the phased recovery strategy proposed by the UK government following the first national lockdown, this paper utilises Greater London as its case study, selecting three main reopening measures (i.e., schools, shops and hospitality reopening). This paper applies sentiment analysis and topic modelling to explore public opinions expressed via Twitter. Our findings reveal that public attention towards the reopening measures reached a peak before the date of policy implementation. The attitudes expressed in discussing reopening measures changed from negative to positive. Regarding the discussed topics related to reopening measures, we find that citizens are more sensitive to early-stage reopening than later ones. This study provides a time-sensitive approach for local authorities and city managers to rapidly sense public opinion using real-time social media data. Governments and policymakers can make use of the framework of sensing public opinion presented herein and utilise it in leading their post-lockdown cities into an adaptive, inclusive and smart recovery.
ABSTRACT
Infection by the severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV-2) is the causative agent of a new disease (COVID-19). The risk of severe COVID-19 is increased by certain underlying comorbidities, including asthma, cancer, cardiovascular disease, hypertension, diabetes, and obesity. Notably, exposure to hormonally active chemicals called endocrine-disrupting chemicals (EDCs) can promote such cardio-metabolic diseases, endocrine-related cancers, and immune system dysregulation and thus, may also be linked to higher risk of severe COVID-19. Bisphenol A (BPA) is among the most common EDCs and exerts its effects via receptors which are widely distributed in human tissues, including nuclear oestrogen receptors (ERα and ERß), membrane-bound oestrogen receptor (G protein-coupled receptor 30; GPR30), and human nuclear receptor oestrogen-related receptor gamma. As such, this paper focuses on the potential role of BPA in promoting comorbidities associated with severe COVID-19, as well as on potential BPA-induced effects on key SARS-CoV-2 infection mediators, such as angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2). Interestingly, GPR30 appears to exhibit greater co-localisation with TMPRSS2 in key tissues like lung and prostate, suggesting that BPA exposure may impact on the local expression of these SARS-CoV-2 infection mediators. Overall, the potential role of BPA on the risk and severity of COVID-19 merits further investigation.